Lanosterol is implicated in cataract formation – it has been proposed to help maintain lens transparency by inhibiting the formation of protein aggregates. Their data confirms that lanosterol synthase and the sterol pathway are upregulated in cataractous lenses. In the study, Dr Avila’s laboratory used lenses that were treated with the stabliser and tissue fixative… Continue reading Expression of oxysterols in human lenses: Implications of the sterol pathway in age-related cataracts
Dr Avila’s laboratory has used vivoPHIX™ to prepare human cataract crystallin proteins. The study aimed to determine the expression of Lanosterol Synthase in human cataractous lenses and their association with α A crystallin protein. Read the research
Nicholas Barry at the MIT Media Lab used vivoPHIX™ for preparing nematodes for fluorescence studies in work titled “Tools for connectomics in C.elegans“ The simplicity of the 302-node nervous system of the nematode C.elegans, makes this an attractive model organism for neuroscientists, however more work is required to fully understand and characterise the function of… Continue reading Tools for connectomics in C.elegans
Mantke et al., demonstrated the use of virusPHIX-P9™ for stablising SARS-CoV-2 Antigen and use by 258 participants across 27 countries for Lateral flow rapid antigen tests, automated point-of-care-tests and laboratory ELISA / immunoassays. Antigen testing has become integral in the ongoing monitoring and detection of COVID-19. Independent and extensive comparative evaluations using data from external… Continue reading Importance of external quality assessment for SARS-CoV-2 antigen detection during the COVID-19
Loop-mediated isothermal amplification (LAMP) has played a crucial role in filling global COVID-19 testing need. ln this study, Moore et al., discuss the use of virusPHIX™ for the stablisation and inactivation of SARS-CoV-2 and eventual detection by LAMP amplification. Read the research
Kate Rawlinson at the Sanger Institute, Hinxton, UK used vivoPHIX™ to preserve RNA of the Schistosome parasite for a ‘circadian clock study’. Due to the Earth’s natural rotations, 24 hour biological rythms are present in most species on Earth. The team addressed these questions using the human blood fluke Schistosoma mansoni that lives in the… Continue reading Daily rhythms in gene expression of the human parasite Schistosoma mansoni
In this paper, Killip et al., (Public Health England) have used RNAssist’s virusPHIX™ reagents to demonstrate SARS-CoV-2 inactivation. We were asked by the UK Department for Health and Social Care to participate in this study for non-guanidine reagents (guanidine being potentially very toxic but commonly used for inactivation). It was great to see these excellent results… Continue reading Virucidal efficacy of guanidine-free inactivants and rapid test buffers against SARS-CoV-2
