Expression of oxysterols in human lenses: Implications of the sterol pathway in age-related cataracts

Lanosterol is implicated in cataract formation – it has been proposed to help maintain lens transparency by inhibiting the formation of protein aggregates. 

Their data confirms that lanosterol synthase and the sterol pathway are upregulated in cataractous lenses. 

In the study, Dr Avila’s laboratory used lenses that were treated with the stabliser and tissue fixative vivoPHIX™. They were then cyropreserved at -70C for immunofluorescence and confocal microscopy analysis. 

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